Melva Silitonga, Putri Windah Sinaga, Herbert Sipahutar, Hendro Pranoto, Adriana Yulinda Dumaria Lumbangaol, Feimmy Ruth Pratiwi Sipahutar, Erlintan Sinaga, Fajar Apollo Sinaga
Excessive alcohol drinking leads to chronic kidney injury (CKI). Bidens pilosa, as a medicinal plant, has promising antibacterial, antimalarial, hepatoprotective, and antidiabetic activities. There is a dearth of information on the therapeutic effect of ethanol extract of Bidens pilosa leaves (EEBP) against alcohol-induced CKI. The exploration of EEBP as renoprotection was evaluated through a comprehensive experimental and pharmacoinformatics analysis. Alcohol (10 ml/kg) was administered for 6 weeks or in combination with EEBP (250, 500, and 750 mg/kg). Induction of alcohol significantly (p ≤ 0.05) increased the total cholesterol, triglyceride, LDL, creatinine, and uremic levels. Furthermore, kidney tissue abnormalities were observed in the alcohol group. The data indicated that EEBP improved the kidney histology and decreased the levels of lipid profile and kidney function parameters. The compounds have the flexibility and stability to bind to active sites of protein, consisting of PPARG, SIRT, HIF1A, and NQO1. This study shows that EEBP exerted an ameliorative effect in alcohol-induced kidney injury. © 2026 Silitonga et al.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, North Sumatra, Indonesia; Bioinformatics Research Group, Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Department of Sports Studies, Universitas Negeri Medan, North Sumatra, Indonesia
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