Erlintan Sinaga, Syafruddin Ilyas, Salomo Hutahaean, Panal Sitorus
Erythrocyte, lymphocyte quantities and spleen histology were observed to investigate the immunostimulatory effect Pirdor leaves ethanolic extract (Saurauia vulcani Korth.) (EES) in white rats (Rattus norvegicus L.) -induced with sheep red blood cell (SRBC) as antigen. Experimental design used in this study was Complete Randomized Design. Twenty four rats were classified into four groups: a control group fed with distilled water (G0), a group treated with sheep red blood cell (SRBC) (G1), a group treated with ethanol extract of pirdot leaves (G2), and a group treated with ethanol extract of pirdot leaves + SRBC (G3) for 31 days. Blood was withrawnThen the red blood cell in white rats were sized by using ABX micros 60. Spleen of white rats were taken and stained by using haematoxylin and eosin to visualize lymphoid follicles. Data were analyzed by one-way ANOVA at 5% significance level. Significant differences were observed in total erythrocytes and spleen histological image which showed a prospect of EES as immunostimulant. © 2019 IOP Publishing Ltd. All rights reserved.
Department of Educational Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Medan, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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