Diky Setya Diningrat, Ayu Nirmala Sari, Novita Sari Harahap, Kusdianti
Brain derived neurotrophic factor (BDNF) concentration has a relationship with Alzheimer's dementia. BDNF is a neurotropin that has a neuroprotective effect on Alzheimer's disease. The BDNF increase in the area around the lesion is closely related to the progress of nerve function recovery. Coix lacryma-jobi leaf ethanol extract is thought to increase the expression of matureBDNF. The purpose of this study was to observe the effect of ethanol extract of hanjeli leaves on the expression of mBDNF in rat brain cells induced by traumatic brain injury as Alzheimer's disease. This research was design in the form of a post test only control group. The number of samples was 33 mice divided into 3 groups, normal mice without treatment (A), trauma model without hanjeli ethanol extract (B) and trauma model group given oral hanjeli ethanol extract 200 mg per weight (kg) (C) every day for 6 days. In the group C, there was an increase in mBDNF expression by an average of 15.81 ± 2.93 compared to group A and B. This study proved that the treatment of hanjeli ethanol extract per oral would increase the expression of mBDNF in brain cells of rat with Alzheimer's induced by traumatic brain injury. © 2021, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Indonesia; Biology Study Program, Faculty of Science and Technology, UIN Ar-Raniry Banda Aceh, Indonesia; Department of Sports Science, Faculty of Sports Science, Universitas Negeri Medan, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences Education, Indonesian University of Education, Bandung, Indonesia
